POLICE have seized allegedly stolen and homemade guns during a Rutherglen raid as part of a major crackdown on supply of firearms and prohibited drugs in the region.

NSW police arrested a 36-year-old female and a 44-year-old male at the property, with more than 130 charges relating to firearm, break and enter and the ongoing supply of prohibited drugs and supply of commercial quantities of drugs, mainly ice in New South Wales and Victoria.

On Thursday, January 9, officers from NSW police Stike Force Nettin executed a raid on a King Street address in Rutherglen with assistance from Victoria Police.

During the search, an allegedly stolen rifle, a privately manufactured firearm, ammunition, firearm parts, tools, and equipment used to manufacture firearms were seized.

At a separate location in the Albury police district officers executed a warrant and located five privately manufactured firearms and parts.

They also seized six firearms, a vehicle, two jet skis and property, which police will allege were stolen.

The alleged offenders were arrested at the Rutherglen property and taken to Wodonga Police, before being extradited to New South Wales, where they were taken to Albury Police Station.

The 36-year-old and 44-year-old were denied bail at Albury Local Court on January 10 and they are set to reappear at the same court on Tuesday, March 4.

The woman was charged with 102 offences while the 44-year-old man was charged with 31 offences relating to gun manufacturing, firearms supply, other gun offences, drug dealing, police pursuit and burglary offences relating to RFS shed break-ins.

Strike Force Nettin was established by officers in the Albury police district to investigate the manufacture and supply of firearms and prohibited drugs across the Murray River region and border towns.

Investigations under Strike Force Nettin continue, with more arrests expected.